American Dad can be very entertaining, with far less mean-spiritedness then Family Guy, with some actually very entertaining humor that's isn't so immature. One of my favorite episodes was actually one called Tear Jerker, a parody and homage the spy films in away that actually got me to laugh.
I generally like American Dad, but it does get a bit repetitive. It is something good to put on in the background when I am not really paying attention, but I want noise and something on the TV. I laugh sometimes and I like much of the satire they do, but they tend to beat a joke until it is dead.