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Congratulations to all winners. These people work very hard for the benefit of millions.
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The process has helped scientists develop models on mice of human disorders from cardiovascular and neuro-degenerative ailments to diabetes and cancer. The citation from the Nobel award committee said the three winners had discovered "principles for introducing specific gene modificiation in mice by the use of embryonic stem cells." The researchers used so-called "knockout mice" - animals whose genetic code has been altered in the lab to either turn on or off certain genes that mice and humans share. The use of gene targeting has helped expand the knowledge of "numerous genes in embryonic development, adult physiology, aging and disease," the citation said. Capecchi, 70, was born in Verona, Italy, and moved to the United States with his mother - a Holocaust survivor - after World War II. He did work that "shed light on the cause of several human inborn malformations," the prize citation said, while Evans, 66, applied gene targeting to develop mouse models for human diseases. |