Prenatal exposure to acetaminophen may increase autism spectrum and hyperactivity symptoms in children
A new study has found that paracetamol (Acetaminophen), which is used extensively during pregnancy, has a strong association with autism spectrum symptoms in boys and for both genders in relation to attention-related and hyperactivity symptoms. Ref. Source 7h.
New neurons reveal clues about an individual's autism
Hallmarks of early brain overgrowth have been discovered in cells of people with autism. These findings suggest that it is possible to use stem cell reprogramming technologies developed in the past decade to model the earliest stages of complex disorders and to evaluate potential therapeutic drugs. Ref. Source 4q.
Mini-brain model of idiopathic autism reveals underlying pathology of neuronal overgrowth
The majority of cases of autism spectrum disorder (ASD) are unknown. Now researchers have created a “mini-brain” model, derived from persons with a particular form of idiopathic ASD characterized by over-sized brains, revealing a defective molecular pathway during brain development that results in early neuronal overgrowth and dysfunctional cortical networks. Ref. Source 6k.
Discovery of male-harming DNA mutation reinforces 'mother's curse' hypothesis
A male-harming DNA mutation has been discovered in Drosophila that demonstrates that the 'mother's curse' -- the possibility that moms may transmit genes to their children that harm their sons but not their daughters - holds true in animals. Ref. Source 2m.
How PSD forms and why defects can cause autism
Scientists have discovered that SynGAP and PSD-95, two abundance proteins in PSD that are known to cause autism when mutated, can form an autonomously assembled network structure both in test-tube and in living cells. The SynGAP/PSD-95 assembly can form stable 'oil-like' droplets in the midst of aqueous cytoplasm of living cells via phase-transition. This finding provides a possible answer for PSD formation in the field of brain science. Ref. Source 5e.
Scientists uncover common cell signaling pathway awry in some types of autism
Skin cells derived from autistic donors grew faster than those from control subjects, and activated their genes in distinct patterns, scientists report. Genes related to cell growth were unusually active, leading to more cells but fewer connections between them. This can cause faulty cell networks unable to properly transmit signals in the brain and enlarged heads during early development, say the researchers. Ref. Source 1j.
Autism severity linked to genetics, ultrasound, data analysis finds
For children with autism and a class of genetic disorders, exposure to diagnostic ultrasound in the first trimester of pregnancy is linked to increased autism severity, according to a new study. Ref. Source 3k.
Parents' age and the risk for autism and schizophrenia: Is the connection real?
A new study indicates that parents who reproduce later in life are more likely to have children who develop autism disorders. Later reproduction was not, however, associated with increased risk for schizophrenia in offspring. Ref. Source 7y.