Serotonin improves sociability in mouse model of autism. Scientists have linked early serotonin deficiency to several symptoms that occur in autism spectrum disorder (ASD). The study examined serotonin levels, brain circuitry, and behavior in a mouse model of ASD. Experiments showed that increasing serotonergic activity in the brain during early development led to more balanced brain activity and improved the abnormal sociability of these mice. Source 7l.
Autism may reflect excitation-inhibition imbalance in brain, study finds. Key features of autism reflect an imbalance in signaling from excitatory and inhibitory neurons in a portion of the forebrain, and that reversing the imbalance could alleviate some of its hallmark symptoms, explain researchers in a new article. Source 9j.
Studies help explain link between autism, severe infection during pregnancy. Two new studies shed light on why mothers who experience an infection severe enough to require hospitalization during pregnancy are at higher risk of having a child with autism. Source 5b.
Infection in pregnant pigs leads to antisocial piglets. When a pregnant woman gets a bad case of the flu, her immune system may react in a way that affects her baby’s developing brain, which could lead to behavioral disorders like autism in the child or schizophrenia in the young adult. The link is well established in humans, which is one reason it’s standard practice to get a flu shot during pregnancy. But until now, the majority of studies testing the underlying causes have been done with rodents, including two that were released just last week. Source 2f.
Multivitamins in pregnancy may be linked to lower autism risk in children. Taking multivitamins during early pregnancy may be associated with a reduced risk of autism spectrum disorder (ASD) in children compared with mothers who do not take multivitamins, finds a study. Source 6t.
In autism, too many brain connections may be at root of condition. Mutations in a gene linked to autism in people causes neurons to form too many connections in rodents, according to a new study. The findings suggest that malfunctions in communication between brain cells could be at the root of autism. Source 1c.