Scientists find gender-distinct circuit for depression. Depression affects women nearly twice as much as men, but unraveling the brain's blueprint that regulates this behavior, let alone identifying specific molecular differences between sexes, has proven difficult. Researchers, however, have found and flipped a switch in the brain, revealing a single circuit in mice that activates during stress and is controlled by testosterone. Source 9l.
I really find this hard to believe. Coming from a male that has been dealing with depression for several years, I can state atleast for myself it gets pretty bad sometimes. I would say that it seems like more women tend to be depressed compared to the amount of males, atleast in my personal experiences.
This could be related to the fact that it's some kind of 'taboo' for a man to have depression, as it's seen as more of a weakness than in women.
Hormonal factors related to the reproductive cycle may play a role in women's vulnerability to depression. Estrogens and progesterone have shown their effect on neurotransmission, neuroendocrine and circadian systems, which have been implicated in mood disorders.