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HIV / AIDS Drugs

HIV drugs tests of 'no benefit'

Expensive tests of HIV/Aids drugs do little to extend survival rates and patients should be treated in their villages, scientists say. Ref. Source 4

Drugs AIDS HIV

Discovery of antibodies could lead to AIDS vaccine

Scientists at The Scripps Research Institute in La Jolla have helped identify two rare and potent human antibodies against HIV, the virus that causes AIDS. Ref. Source 3

HIV / AIDS Drugs Health & Special Psychology

Doctors: Patents keep HIV drugs too pricey to use

The medical aid group said at an international AIDS meeting in Kuala Lumpur, Malaysia that prices of older drugs long used to treat patients have fallen sharply as India and other countries make generics. But newer drugs that are more effective against the AIDS virus are too expensive, costing up to 15 times more.

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Drugs AIDS HIV

Zinc deficiency may contribute to increased inflammation among HIV-positive individuals

Researchers report that zinc deficiency may contribute to chronic inflammation among HIV-positive individuals. Theirs is believed to be the first investigation to explore the association between serum zinc levels and inflammation among people with human immunodeficiency virus (HIV) infection, while taking their anti-retroviral therapy into account. Ref. Source 1j.

Drugs AIDS HIV

Neutrons probe structure of enzyme critical to development of next-generation HIV drugs

Medical researchers used neutron analysis to better understand a protein implicated in the replication of HIV, the retrovirus that causes AIDS. The enzyme, known as HIV-1 protease, is a key drug target for HIV and AIDS therapies. The multi-institutional team used neutron crystallography to uncover detailed interactions of hydrogen bonds at the enzyme’s active site, revealing a pH-induced proton ‘hopping’ mechanism that guides its activity. Ref. Source 7s.

HIV / AIDS Drugs

HIV 'safe houses' identified inside the body

Researchers have identified cells that provide 'safe houses' for the human immunodeficiency virus during antiretroviral therapy. HIV needs to be "Housed" in a cell, a safe haven, so to speak, to live and replicate, explain authors of a new report. Ref. Source 9b.

HIV / AIDS Drugs

Antibody supresses HIV in infected individuals

The antibody VRC01 proves safe for individuals infected with HIV-1, but only modestly controls the virus in participants who stop receiving antiretroviral therapy, report scientists. Ref. Source 4t.

HIV / AIDS Drugs Psychology Special & Health

HIV: A therapeutic advance for resource-limited settings. A clinical trial running in parallel in three countries in sub-Saharan Africa, shows that dual therapy with lamivudine and a boosted protease inhibitor is effective as second-line treatment in patients infected by HIV with multiple mutations. Such treatment deescalation will reduce costs, side effects, and the need for virological monitoring of patients. Source 8m.